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Optimization Of Design Space And Throughput Conditions For Scale Up Of A Low- Dose Roller Compacted Product
2015-01-20 11:23:07| drugdiscoveryonline Downloads
Roller compaction of low dose active pharmaceutical ingredients into solid dosages forms is quite challenging. Ribbon porosity, tensile strength, mean granule size and surface area are key quality attributes that can affect downstream processing and final product performance. These parameters were evaluated in the present study to establish a design space and operational conditions for roller compaction of a placebo tablet blend that closely mimics the formulation requirements of low dose pharmaceutical active ingredients. This study also helps to minimize the API need that often in limited supply during early stage of drug development.
Tags: conditions
design
product
low
Category:Biotechnology and Pharmaceuticals