Challenges facing hot countries regarding finding refrigerant alternatives for HCFC-22 in residential air-conditioning will be discussed in seminar chaired by Walid Chakroun at ASHRAE 2016 Winter Conference, which will take place January 23–27, 2016 in Orlando, FL. Technical Program will feature 8 tracks, ~100 sessions, and 300+ speakers. Topics will include test outcomes and results comparison meant to explore possible workable refrigerant alternatives for high ambient operation.