Vaccinations could lead to the end of shingles The vaccine is 60-70 percent effective at decreasing the severity or preventing shingles. Check out this story on sctimes.com: http://www.sctimes.com/story/life/wellness/2014/10/25/vaccinations-lead-end-shingles/17917375/ Registered pharmacist David Thomas shows a vile of the new shingles vaccine Wednesday at the CentraCare Health Plaza pharmacy.