Able to cryo-immobilize samples without introducing structural alteration, Leica EM ICE lets users synchronize high-pressure freezing and light stimulation with 1 msec precision to capture dynamic phenomena and further analyze them at nanometer resolution. There are 5 wavelengths for light stimulation, and up to 9 samples can be frozen consecutively with sample storage system. Light stimulation can be performed with different wavelengths due to built-in connection for LED light modules.