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Structure-based design used as tool for engineering deimmunized biotherapeutics
2015-02-15 14:01:32| Biotech - Topix.net
In the first experimental use of algorithms that employ structure-based molecular modeling to optimize deimmunized drug candidates, researchers complement their prior sequence-based deimmunizing algorithms and expand the tool kit of protein engineering technologies to use in next generation drug development. The P99 beta lactamase peptide backbone is shown in complex with a beta lactam substrate , which is rendered as a stick figure with carbon in cyan, nitrogen in dark blue, oxygen in red, and sulfur in yellow.
Tags: design
tool
engineering
design tool
Category:Biotechnology and Pharmaceuticals