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Tag: space
Optimization Of Design Space And Throughput Conditions For Scale Up Of A Low- Dose Roller Compacted Product
2015-01-20 11:23:07| drugdiscoveryonline Downloads
Roller compaction of low dose active pharmaceutical ingredients into solid dosages forms is quite challenging. Ribbon porosity, tensile strength, mean granule size and surface area are key quality attributes that can affect downstream processing and final product performance. These parameters were evaluated in the present study to establish a design space and operational conditions for roller compaction of a placebo tablet blend that closely mimics the formulation requirements of low dose pharmaceutical active ingredients. This study also helps to minimize the API need that often in limited supply during early stage of drug development.
Tags: conditions
design
product
low
Determining Design Space and Scale Up Conditions in Roller Compaction
2015-01-20 11:23:07| drugdiscoveryonline Downloads
By Prasad.VN Challapalli1, Manaud de Raspide2, Satish Kamath3, and Ram Kasina4 1 Pharmaceutical Development Services, Patheon Pharmaceuticals Inc. Cincinnati, OH USA 2 Actelion Pharmaceuticals, Ltd, Allschwil, Switzerland 3 GlaxoSmithKline, Parsippany, NJ, USA 4 McNeil Consumer Healthcare, Fort Washington, PA, USA ABSTRACT Roller compaction of low dose active pharmaceutical ingredients into solid dosages forms is quite challenging. Ribbon porosity, tensile strength, mean granule size and surface area are key quality attributes that can affect downstream processing and final product performance. These parameters were evaluated in the present study to establish a design space and operational conditions for roller compaction of a placebo tablet blend that closely mimics the formulation requirements of low dose pharmaceutical active ingredients. This study also helps to minimize the API need that often in limited supply during early stage of drug development.
Tags: conditions
design
space
scale
Food writer Richard Foss brings 'Food in the Air and Space' down to earth
2015-01-20 07:29:35| Beverages - Topix.net
Food in the Air and Space author Richard Foss with an Airbus 319 painted with Pacific Southwest Airline colors. The airplane is on display at the Flight Path Museum near LAX.
DSTI Furthers Space Innovation with Advanced Radiator Technology
2015-01-19 11:30:51| Industrial Newsroom - All News for Today
MINNEAPOLIS, Minn. DSTI is on a path to travel out of this world with its latest fluid and electrical transfer solution designed for use in future spacecraft. DSTI and the Naval Research Laboratory (NRL) in Washington, D.C. have made large steps in the innovation of spacecraft thermal control system (TCS...
Tags: advanced
technology
space
innovation
Primoceler and ON Semiconductor Partnering to Deliver CMOS Sensor Solutions to European Space Agency
2015-01-19 11:30:51| Industrial Newsroom - All News for Today
TAMPERE, Finland A proven innovator in laser and glass welding technologies, Primoceler (www.primoceler.com) is pleased to announce a new contract with the European Space Agency to design and manufacture complete CMOS sensor packages for orbital missions. Working with Primoceler on this contract will be ON...
Tags: space
solutions
agency
european
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