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Kinetic Ligand Binding And 3D Tumor Invasion Technologies To Assess Drug Residence Time And Anti-metastatic Effects
2015-04-17 17:03:22| drugdiscoveryonline Downloads
Metastasis, the spread of cancer cells from the original tumor to secondary locations within the body, is linked to approximately 90% of cancer deaths. The expression of chemokine receptors, such as CXCR4 and CCR7, is tightly correlated with the metastatic properties of breast cancer cells. In vivo, neutralizing the interaction of CXCR4 and its known ligand, SDF1-α (CXCL12), significantly impaired the metastasis of breast cancer cells and cell migration.
Tags: time
effects
drug
technologies
Aspira Scientific Launches Cy*Phine for Drug and Material Development
2015-04-17 12:31:14| Industrial Newsroom - All News for Today
Delivering next generation tool developed by A*STAR for efficient cross-coupling chemistry SAN FRANCISCO - Aspira Scientific, Inc. (Milpitas, California) announced the launch of Cy*Phine, a novel terarylphosphine system for efficient cross-coupling chemistry. The importance of cross-coupling chemistry was...
Tags: development
material
scientific
drug
Approved Pfizer breast cancer drug impresses in latest study
2015-04-16 12:55:11| Biotech - Topix.net
Pfizer Inc said on Wednesday the first formal late-stage trial of its approved treatment for advanced breast cancer, Ibrance, was stopped early after the medicine met its goal of delaying progression of the disease in previously treated patients. J.P.Morgan analyst Chris Schott said in a research note that the successful trial results should boost demand for the recently approved treatment, which works differently than approved medicines and has blockbuster sales potential.
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FDA Approves New Type Of Heart Failure Drug
2015-04-16 05:56:10| Biotech - Topix.net
Patients with chronic heart failure, a disabling, deadly disease that worsens as the heart gradually pumps less efficiently, are getting a much-needed new option with U.S. approval Wednesday of a novel drug from Amgen Inc. Corlanor is the first medication in a dozen years for heart failure, which is becoming more common with obesity - and more people surviving heart attacks due to better treatments. Meanwhile, the Food and Drug Administration is reviewing another heart failure pill, from Novartis AG, and could approve it this summer.
Drug giant pledges $100 million investment at East Bay facility
2015-04-15 16:21:53| Chemicals - Topix.net
Bayer HealthCare will spend $100 million to build a new product testing facility in Berkeley for new generations of its top-selling hemophilia A drugs. The 80,000-square-foot structure on the southern edge of Bayer's East Bay campus actually is part of a long-range strategy by the subgroup of Germany-based drug giant Bayer AG.
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