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Spending billions but coming up short on the trust scale

2015-01-25 20:03:29| Auto Dealers - Topix.net

Automotive data available for graphing, exporting and viewing static data tables. Must have a data center subscription to access content.

Tags: short coming scale trust

Optimization Of Design Space And Throughput Conditions For Scale Up Of A Low- Dose Roller Compacted Product

2015-01-20 11:23:07| drugdiscoveryonline Downloads

Roller compaction of low dose active pharmaceutical ingredients into solid dosages forms is quite challenging. Ribbon porosity, tensile strength, mean granule size and surface area are key quality attributes that can affect downstream processing and final product performance. These parameters were evaluated in the present study to establish a design space and operational conditions for roller compaction of a placebo tablet blend that closely mimics the formulation requirements of low dose pharmaceutical active ingredients. This study also helps to minimize the API need that often in limited supply during early stage of drug development.

Tags: conditions design product low

Determining Design Space and Scale Up Conditions in Roller Compaction

2015-01-20 11:23:07| drugdiscoveryonline Downloads

By Prasad.VN Challapalli1, Manaud de Raspide2, Satish Kamath3, and Ram Kasina4 1 Pharmaceutical Development Services, Patheon Pharmaceuticals Inc. Cincinnati, OH USA 2 Actelion Pharmaceuticals, Ltd, Allschwil, Switzerland 3 GlaxoSmithKline, Parsippany, NJ, USA 4 McNeil Consumer Healthcare, Fort Washington, PA, USA ABSTRACT Roller compaction of low dose active pharmaceutical ingredients into solid dosages forms is quite challenging. Ribbon porosity, tensile strength, mean granule size and surface area are key quality attributes that can affect downstream processing and final product performance. These parameters were evaluated in the present study to establish a design space and operational conditions for roller compaction of a placebo tablet blend that closely mimics the formulation requirements of low dose pharmaceutical active ingredients. This study also helps to minimize the API need that often in limited supply during early stage of drug development.

Tags: conditions design space scale

Scale Computing preps to launch large expansion

2015-01-18 05:57:12| IT Services - Topix.net

Information technology firm Scale Computing Inc. has been raising money at a clip similar to other prominent local tech companies in their early days and is gearing up to increase its workforce by a factor of five.

Tags: large scale expansion computing